JAMES E. DOHERTY, M.D., F.A.C.P.; WILLIAM H. PERKINS, M.D., F.A.C.P.
Interest in the action of digitalis in thyroid disease has been stimulated recently by the studies of Frye and Braunwald (1), which demonstrated that larger than the usual dose of acetyl strophanthadin was necessary to control the ventricular rate in hyperthyroid patients with atrial fibrillation. Smaller doses than usual would control the ventricular rate in patients with myxedema. These results are supported by many other clinical and experimental observations (2-6).
We have published our findings of the serum levels, turnover rates, and excretion of digoxin in euthyroid patients after oral (7), intravenous (8), and intramuscular (9) administration of tritiated (radioactive
DOHERTY JE, PERKINS WH. Digoxin Metabolism in Hypo- and Hyperthyroidism: Studies with Tritiated Digoxin in Thyroid Disease. Ann Intern Med. ;64:489–507. doi: 10.7326/0003-4819-64-3-489
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Published: Ann Intern Med. 1966;64(3):489-507.
Endocrine and Metabolism, Thyroid Disorders.
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