DONALD E. MAYNARD, PH.D.; ROBERT L. FOLK, M.D.; THOMAS R. RILEY, M.D.; RALPH G. WIELAND, M.D., F.A.C.P.; GRANT GWINUP, M.D.; GEORGE J. HAMWI, M.D., F.A.C.P.
The use of repeated infusions of adrenocorticotrophic hormone (ACTH) requiring 24-hour urine collections for 1 to 3 days has gained widespread acceptance in defining the functional integrity of the human adrenal cortex. However, the inconvenience of an infusion and the time required for specimen collection and measurement of urinary 17-hydroxycorticosteroids combine to make this procedure quite cumbersome.
Other tests based on the response of plasma 17-hydroxycorticosteroids to infused ACTH (1, 2) still possess the discomfort and inconvenience of an infusion and rely on the laborious technique of measuring plasma 17, 21-dihydroxy-20-ketosteroids. Furthermore, this latter measurement (2) will include nonsteroidal substances
MAYNARD DE, FOLK RL, RILEY TR, WIELAND RG, GWINUP G, HAMWI GJ. A Rapid Test for Adrenocortical Insufficiency. Ann Intern Med. ;64:552–556. doi: 10.7326/0003-4819-64-3-552
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Published: Ann Intern Med. 1966;64(3):552-556.
Adrenal Disorders, Endocrine and Metabolism, Prevention/Screening.
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