LAWRENCE D. PETZ, M.D.; JOSEPH R. GOODMAN, PH.D.
Hemolytic anemia on a mechanical basis has been well documented as an unusual complication of the use of prosthetic cardiovascular materials (1-12). The characteristic features of mechanical hemolytic anemia are the presence of numerous irregularly contracted erythrocytes in the blood film associated with signs of intravascular hemolysis (absent serum haptoglobin, elevated plasma hemoglobin, hemoglobinuria, and hemosiderinuria). However, the question still remains as to why some patients with artificial cardiovascular prostheses have clinically significant hemolysis whereas a majority do not (1, 2).
The purposes of this paper are:  to report two patients who developed hemolytic anemia after insertion of the
LAWRENCE D. PETZ, JOSEPH R. GOODMAN. Ringed Sideroblasts and Intramitochondrial Iron in Cases of Mechanical Hemolytic Anemia: Significance of These Findings and Observations on the Etiology of Hemolysis. Ann Intern Med. 1966;64:635–643. doi: 10.7326/0003-4819-64-3-635
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Published: Ann Intern Med. 1966;64(3):635-643.
Hematology/Oncology, Red Cell Disorders.
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