GEORGE J. ELLIS, M.D.; RICHARD I. BREUER, M.D.; EDWARD E. OWEN, M.D.; JOHN LASZLO, M.D.
The relationship between vitamin B12 metabolism and the diseases of B12 deficiency has been so well studied in the past few decades that it has become unusual to encounter clinical problems that fall outside the recognized patterns and appear to violate established principles. The following is a report of such a case: a patient with an inability to utilize vitamin B12 due to both small bowel malabsorption and lack of intrinsic factor, who during the course of adequate parenteral vitamin B12 administration developed clinical evidence of combined systems disease. Some possible mechanisms were explored and are discussed below.
Patient
ELLIS GJ, BREUER RI, OWEN EE, LASZLO J. Pernicious Anemia and Malabsorption, with Spinal Cord Degeneration Developing During Vitamin B12 Treatment. Ann Intern Med. ;64:654–658. doi: 10.7326/0003-4819-64-3-654
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© 2018
Published: Ann Intern Med. 1966;64(3):654-658.
DOI: 10.7326/0003-4819-64-3-654
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Hematology/Oncology, Neurology, Red Cell Disorders.
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