M. F. GLYNN, M.D., F.R.C.P.(C); E. A. MURPHY, M.D.; J. F. MUSTARD, M.D. F.R.C.P.(C)
The characteristics of thrombi, in particular arterial thrombi, were delineated during the latter part of the nine-teenth century. It was shown that the initial step involved the formation of platelet aggregates (1-3). Further growth led to a structure consisting of masses of platelets interspersed with layers of fibrin and red blood cells (3). Within hours the platelet mass usually diminishes, and fibrin becomes the prominent component (3, 4). In man, thrombus material is usually not available until much of this transformation has occurred. Thus, there has been a tendency to lose sight of the basic importance of the platelet. Rightly
GLYNN MF, MURPHY EA, MUSTARD JF. Platelets and Thrombosis. Ann Intern Med. ;64:715–719. doi: 10.7326/0003-4819-64-3-715
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Published: Ann Intern Med. 1966;64(3):715-719.
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