DAVID A. OGDEN, M.D.; JOSEPH H. HOLMES, M.D., F.A.C.P.
Initial technical success is usually achieved in human renal transplantation. Subsequent survival of the homograft and of the patient requires successful control of graft rejection. Early recognition of transplant rejection is requisite to successful reversal of rejection.
Renal homograft rejection may be clinically manifest by fever, exacerbation of hypertension, tenderness at the transplant site, weight gain, edema, malaise, mental depression, anorexia, and arthralgia (1-4). Oliguria accompanied by proteinuria (2), lymphocytes in the urine sediment (3), and urinary enzyme alterations (5) may occur. A secondary increase in blood urea nitrogen (BUN) and serum creatinine associated with a decrease in creatinine clearance
OGDEN DA, HOLMES JH. Urinary Solute Excretion as an Index of Renal Homograft Rejection. Ann Intern Med. 1966;64:806–816. doi: 10.7326/0003-4819-64-4-806
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Published: Ann Intern Med. 1966;64(4):806-816.
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