EDWARD R. BURKA, M.D.; ZEBULON WEAVER III, M.D.; PAUL A. MARKS, M.D.
The susceptibility of certain subjects to primaquine-induced hemolytic anemia was first associated with an intrinsic abnormality of the erythrocytes by Dern and coworkers (1). Subsequent investigations (2-5) demonstrated that the major defect in erythrocytes of these subjects is a deficiency of glucose-6-phosphate dehydrogenase (G-6PD) activity. It is now recognized that hemolytic episodes may occur in affected subjects after exposure to a large number of agents (6-8). Present evidence indicates that G-6PD deficiency is probably one of the most prevalent hereditary enzymatic defects of clinical significance. This report summarizes our clinical experience with anemia associated with G-6PD deficiency over a 6-year
EDWARD R. BURKA, ZEBULON WEAVER, PAUL A. MARKS. Clinical Spectrum of Hemolytic Anemia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency. Ann Intern Med. 1966;64:817–825. doi: 10.7326/0003-4819-64-4-817
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Published: Ann Intern Med. 1966;64(4):817-825.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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