F. Eugene Tubbs, M.D.; Yoshiharu Sako, M.D.; Lamar E. Crevasse, M.D. (Associate)
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Thiamine-deficient hearts have been demonstrated by light microscopy to show interstitial edema with hydropic and fatty degeneration of the myocardial fibers. This report is the first ultrastructure study of thiamine-deficient cardiac muscle. Twenty-four adult male Sprague-Dawley rats were divided into two groups. Controls were fed a standard balanced diet containing 2.2 mg of thiamine 100 g of diet. The other group received the same diet, without thiamine. The thiamine-deficient group rapidly developed beri-beri, manifest by weakness, weight loss, epilation and labored respirations. They were given 5 µg of thiamine occasionally to maintain life and induce a chronic deficient state. After
Tubbs FE, Sako Y, Crevasse LE. An Electromicroscopic Study of the Thiamine-Deficient Rat Heart.. Ann Intern Med. ;64:1154. doi: 10.7326/0003-4819-64-5-1154_1
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Published: Ann Intern Med. 1966;64(5):1154.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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