Lamar E. Crevasse, M.D. (Associate); Yoshiharu Sako, M.D.; Myron W. Wheat Jr., M.D.
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Tritium-labeled quinidine (Wilzbach method), 50 mg/kg by mouth, was given to mongrel dogs. Serum, urine, bile, and myocardial radioactivity were determined simultaneously.
In six acute experiments serum levels of quinidine peaked in 2 hours, were accompanied by immediate appearance of urinary radioactivity which peaked in 1 to 2 hours and accounted for the major excretory pathway. Biliary radioactivity was somewhat delayed, reaching a peak 2 to 4 hours after administration.
Serum and myocardial levels of tritiated quinidine were correlated at 2, 4, 6, 12, and 24 hours, after a single dose of quinidine. Serum levels fell in linear fashion, being
Lamar E. Crevasse, Yoshiharu Sako, Myron W. Wheat. The Metabolism and Distribution of Tritiated Quinidine.. Ann Intern Med. 1966;64:1156. doi: 10.7326/0003-4819-64-5-1156_3
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Published: Ann Intern Med. 1966;64(5):1156.
Cardiology, Rhythm Disorders and Devices.
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