George E. Burch, M.D., F.A.C.P.; N. P. DePasquale, M.D., F.A.C.P.
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Normal mitral valve function depends upon the maintenance of the proper spatial relationships between the papillary muscles, the chordae tendinae, and the mitral valve leaflets throughout the cardiac cycle. Papillary muscle dysfunction may occur as a result of (1) ischemia or infarction of a papillary muscle, (2) ventricular dilatation (including aneurysm), (3) rupture of a papillary muscle, (4) inflammatory disease of a papillary muscle, and (5) interventricular conduction disturbances.
Papillary muscle dysfunction results in mitral regurgitation and an apical systolic murmur. The characteristics of the murmur vary depending upon the etiology of the papillary muscle dysfunction. In the case of
Burch GE, DePasquale NP. Papillary Muscle Dysfunction.. Ann Intern Med. 1966;64:1157. doi: 10.7326/0003-4819-64-5-1157_1
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Published: Ann Intern Med. 1966;64(5):1157.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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