John A. Linfoot, M.D.; Joseph F. Garcia, Ph.D.; Edward Manougian, M.D.; Malcolm Powell, M.D.; James Born, M.D.; John H. Lawrence, M.D., F.A.C.P.
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The availability of a sensitive radio-immunoassay for growth hormone has made it possible to study pituitary function by directly measuring the capacity of the pituitary to release growth hormone in response to hypoglycemia. A sensitive radio-immunoassay was employed in the study of growth hormone levels in patients with various pituitary diseases, including acromegaly (20), chromophobe adenoma (4), Chiari-Frommel syndrome (2), postsurgical hypopituitarism (3), and Cushing's syndrome (4). Similar studies were carried out in normal subjects (4), and patients with breast carcinoma (22) and diabetic retinopathy (7) who had received heavy-particle pituitary irradiation from the 184-in. cyclotron.
Modified insulin tolerance tests
Linfoot JA, Garcia JF, Manougian E, Powell M, Born J, Lawrence JH. Hypoglycemia Induced Growth Hormone Secretion in Pituitary Diseases.. Ann Intern Med. ;64:1159. doi: 10.7326/0003-4819-64-5-1159_2
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Published: Ann Intern Med. 1966;64(5):1159.
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