Leonard Laster, M.D. (Associate); Robert K. Ockner, M.D.; Minnie L. Woodson, B.S.
This content is PDF only. Please click on the PDF icon to access.
In vivo studies have shown bile salts influence not only intestinal absorption of sterols but also intestinal synthesis of sterols. We assayed scrapings of guinea pig small-intestine mucosa in vitro for incorporation of isotope from 14C-precursors into C27-sterols. Activity was greater in distal gut; animals varied markedly (1965). To test bile salt effects in vitro, we studied incorporation of acetate-2-14C or mevalonate-2-14C into C27 sterols by paired mucosal scrapings from proximal or distal small intestine of a given animal. One flask contained no bile salt, the other either mixed bile salts (TC-GC) or purified taurocholate (TC) or glycocholate (GC).
Laster L, Ockner RK, Woodson ML. Bile Salt Inhibition of Sterol Biosynthesis by Small-intestine Mucosa in Vitro.. Ann Intern Med. ;64:1161. doi: 10.7326/0003-4819-64-5-1161_2
Download citation file:
Published: Ann Intern Med. 1966;64(5):1161.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use