Donald D. Funk, M.D.; Clement A. Finch, M.D.
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Erythroid marrow function has been evaluated in a variety of hematologic disorders by ferrokinetic measurements including plasma iron turnover rate, red cell utilization, marrow transit time, and body scanning.
Comparison of hepatic, splenic, and sacral uptake of plasma sound radioiron-59 with plasma radioiron-59 disappearance demonstrates that only marrow and liver are capable of removing iron directly from transferrin. Parenchymal iron loading is indicated by primary liver uptake of activity. Myeloid metaplasia is detected by initial uptake by spleen and differs from early red cell destruction and splenic sequestration by the timing of tissue activity accumulation. Plasma activity localizes in marrow
Funk DD, Finch CA. A Classification of Anemia Based on Functional Activity of the Erythroid Marrow.. Ann Intern Med. ;64:1163. doi: 10.7326/0003-4819-64-5-1163_1
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Published: Ann Intern Med. 1966;64(5):1163.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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