Samuel Charache, M.D.; David J. Weatherall, M.D.; John B. Clegg, Ph.D.
This content is PDF only. Please click on the PDF icon to access.
Polycythemia was encountered in a family heterozygous for an abnormal hemoglobin with an unusual affinity for oxygen. The propositus was an 81-year-old man with a hematocrit reading of 58%. In three generations of his family, carriers of the abnormal hemoglobin had significantly higher hematocrit readings than did normal individuals. The red cells of heterozygotes were normal in appearance, and the white cells and platelets appeared normal on blood smears. The abnormal hemoglobin comprised 28 to 35% of hemolysates from affected individuals. At pH 8.6 it migrated between hemoglobins A and I. The amino acid substitution was localized to amino acid
Samuel Charache, David J. Weatherall, John B. Clegg. Polycythemia Associated with a Hemoglobinopathy.. Ann Intern Med. 1966;64:1165. doi: 10.7326/0003-4819-64-5-1165_1
Download citation file:
Published: Ann Intern Med. 1966;64(5):1165.
Hematology/Oncology, Red Cell Disorders.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use