Robert A. Phillips, M.D.
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After a brief historical introduction, the pathophysiology of cholera will be discussed.
The electrolyte composition of the cholera stool at rates greater than 4 ml/kg/hr is quite constant at Na + 140, K + 10, Cl - 110, and HCO3 - 40 mEq/liter (± 5 mEq/liter). Because of this, a standard method for the treatment of cholera by the intravenous route was feasible.
Diarrhea can mean only that the absorptive capacity of the intestine for water and electrolytes has been exceeded.
The defect can be a failure of absorption ("poisoning of the sodium pump"), an enhanced plasma → gut lumen
Phillips RA. The James D. Bruce Memorial Lecture: Cholera from the Perspective of 1966.. Ann Intern Med. ;64:1169. doi: 10.7326/0003-4819-64-5-1169_1
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Published: Ann Intern Med. 1966;64(5):1169.
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