Joseph Post, M.D., F.A.C.P.; Joseph Hoffman, M.D.
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Tumor chemotherapy is predicated upon the selective destruction of tumor cells in relation to normal cells. Clinical experience has shown that normal bone marrow and intestinal cells usually are destroyed whether or not tumor cells are altered.
Studies to be reported are of the cells of three experimentally-induced rat tumors—hepatoma, breast tumor, and sarcoma of connective tissue. These have shown replication and deoxyribonucleic acid (DNA) synthesis times three to four times slower than those of their respective coexistent ileal epithelium. Further, at a given time, many more ileal cells are replicating than are tumor cells.
Accordingly, if the rat be
Post J, Hoffman J. The Replication of Autogenous Tumor Cells "in Vivo": Relation to Chemotherapy.. Ann Intern Med. ;64:1177. doi: 10.7326/0003-4819-64-5-1177_2
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Published: Ann Intern Med. 1966;64(5):1177.
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