Larry Nathanson, M.D.; Thomas C. Hall, M.D., F.A.C.P.
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Numerous authors have reported disorders of multiple organ systems as distant effects of the presence of cancer. These have heretofore been treated as medical curiosities, and there is a need for rational pathophysiological explanation. Since they may herald the onset of clinical cancer they may contain clues as to the nature of the neoplastic process. In addition, such gross derangements as hypercalcemia and Cushing's may contribute importantly to the patients' morbidity.
The unexpectedly high frequency of such paraneoplastic syndromes when looked for is indicated by our recognition of 104 cases over a brief period. They fell into definable clinical categories,
Nathanson L, Hall TC. A Unifying Concept of the Paraneoplastic States.. Ann Intern Med. ;64:1178. doi: 10.7326/0003-4819-64-5-1178_1
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Published: Ann Intern Med. 1966;64(5):1178.
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