Carlos A. Vaamonde, M.D.; Liliana S. Vaamonde, M.D.; Hugo J. Morosi, M.D.; Eugene L. Klingler Jr., M.D.; Solomon Papper, M.D., F.A.C.P.
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Renal concentrating ability was studied in 11 patients with cirrhosis of the liver and in 9 patients with chronic disease not involving the liver ("controls"). None had evidence of cardiovascular or renal disease. All received a diet containing 10 mEq sodium, 80 mEq of potassium and 1.5 gm/kg of protein daily. In each subject we determined: (1) maximum urine osmolality after 16 hours of deyhdration, (2) maximum osmolality after a 3-hour infusion of vasopressin during a sustained water load and, (3) free water clearance during a mannitol diuresis (Table).
No difference was observed in inulin clearance, para-amino hippurate clearance, or
Vaamonde CA, Vaamonde LS, Morosi HJ, Klingler EL, Papper S. Renal Concentrating Ability in Cirrhosis of the Liver.. Ann Intern Med. ;64:1183. doi: 10.7326/0003-4819-64-5-1183_1
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Published: Ann Intern Med. 1966;64(5):1183.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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