Harvey J. Dworken, M.D., F.A.C.P.; Vaun Newill, M.D.
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In evaluating responses of patients to drug and therapeutic programs, most investigators recognize that adequate controls, avoidance of bias, and tests of statistical significance are essential to the validity of the study. Despite this, poorly designed studies are still being reported largely because many physicians do not understand the planning techniques. Pharmaceutical houses often use these results in journal advertising, thereby perpetrating possibly faulty conclusions.
It is the purpose of this presentation to show how a study was designed to compare the effects of a belladonna-amobarbital combination with a dummy preparation in the short-term therapy of patients with the irritable
Dworken HJ, Newill V. Framing a Clinical Trial.. Ann Intern Med. ;64:1184. doi: 10.7326/0003-4819-64-5-1184_3
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Published: Ann Intern Med. 1966;64(5):1184.
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