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During the past 2 decades, rheumatic fever has been the beneficiary of more concentrated clinical and epidemiological investigation than almost any other major human illness. Large populations of patients have been studied in massive clinical trials planned to compare antistreptococcal or anti-inflammatory techniques of preventing initial attacks of rheumatic fever, recurrent attacks, and residual heart disease. The scientific quality of the investigations has been aided by improved laboratory and clinical methods for detecting streptococcal infections, for excluding other diseases that formerly masqueraded as rheumatic fever, for identifying the degree of rheumatic cardiac involvement, and for statistical analysis of results.
Rheumatic Fever: Diagnosis, Management and Prevention.. Ann Intern Med. 1966;64:1189–1190. doi: 10.7326/0003-4819-64-5-1189_2
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Published: Ann Intern Med. 1966;64(5):1189-1190.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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