JEROME M. HERSHMAN, M.D.
Hyperthyroidism is a syndrome of metabolic and pathologic disturbances resulting from the action of excessive circulating thyroid hormone on peripheral tissues. In 1835, Robert Graves (1)1 recorded the history of a young lady with nervousness, severe palpitation, weakness, weight loss, exophthalmos, and enlargement of the thyroid which was at first soft but then became firmer and asymmetrical. Ninety-three years later, Plummer (4) differentiated hyperthyroidism associated with nodular goiter without exophthalmos from Graves' disease. However, there are many cases intermediate between the conditions described by Graves and Plummer which tend to obscure the distinction between them (5). Diffuse goiter may become
HERSHMAN JM. The Treatment of Hyperthyroidism. Ann Intern Med. ;64:1306–1314. doi: 10.7326/0003-4819-64-6-1306
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Published: Ann Intern Med. 1966;64(6):1306-1314.
Endocrine and Metabolism, Thyroid Disorders.
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