THOMAS K. BURNHAM, M.B.; GERALD FINE, M.D.; THOMAS R. NEBLETT, M.B., PH.D.
Autoantibodies to nuclear and cytoplasmic constituents are characteristically present in connective tissue diseases or "autoimmune" processes. The lupus erythematosus (LE) cell test was the first practical demonstration of an antinuclear antibody that was found to be in the gamma globulin fraction of sera from patients with systemic lupus erythematosus (SLE) (1). With the advent of the indirect fluorescent antibody technique, more antinuclear factors became demonstrable. Antinuclear antibodies are present in the immunoglobulin classes, gamma 2 (gamma G or IgG), gamma 1A (gamma A or IgA), and gamma 1M (gamma M or IgM) (2) and lack organ and species specificity. Thus
BURNHAM TK, FINE G, NEBLETT TR. The Immunofluorescent Tumor Imprint Technique: II. The Frequency of Antinuclear Factors in Connective Tissue Diseases and Dermatoses. Ann Intern Med. ;65:9–19. doi: 10.7326/0003-4819-65-1-9
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Published: Ann Intern Med. 1966;65(1):9-19.
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