STEPHEN E. EPSTEIN, M.D.; EUGENE BRAUNWALD, M.D., F.A.C.P.
Two of the more prominent manifestations of impaired cardiac function are an inability to augment the cardiac output appropriately in response to increased metabolic demands, and a diminished ability to excrete sodium, with resultant fluid accumulation and edema. Since it has recently been observed that the cardiac response to maximal and submaximal levels of exercise in both normal subjects and patients with various forms of heart disease is reduced by blockade of the beta adrenergic receptors (1), it became of interest to determine if this impairment of hemodynamic performance is associated with changes in the patterns of sodium excretion. A
EPSTEIN SE, BRAUNWALD E. The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion: Studies in Normal Subjects and in Patients with Heart Disease. Ann Intern Med. ;65:20–27. doi: 10.7326/0003-4819-65-1-20
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Published: Ann Intern Med. 1966;65(1):20-27.
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