HARVEY E. GRODE, M.D.; JOHN LASZLO, M.D.
A patient is reported with sickle trait, refractory anemia, and nutritional anemia, whose red cells were found to alter the percentage of A and S hemoglobin by nongenetic factors. While it is unusual but not surprising to discover a patient with this combination of anemias, it is remarkable to find a concomitant alteration in hemoglobin expression.
A clinical summary on this patient is presented and possible mechanisms discussed.
V.A.H. 4805, a 40-year-old Negro handyman, had a pertinent medical history dating back to July, 1950, when he consulted a physician because of dizziness, weakness, throbbing headache, and vomiting. At
GRODE HE, LASZLO J. Sickle Cell Trait, Refractory Anemia, and Nutritional Anemia with Variable Expression of A and S Hemoglobin. Ann Intern Med. ;65:321–325. doi: 10.7326/0003-4819-65-2-321
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Published: Ann Intern Med. 1966;65(2):321-325.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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