BERNARD PIROFSKY, M.D., F.A.C.P.
In recent years, surgical procedures have been developed to correct various forms of heart disease by the insertion of prosthetic devices. A hemolytic anemia that unexpectedly resulted from these procedures has presented the physician with a new syndrome having profound clinical and theoretical significance. This hemolytic anemia was first noted in the human and in experimental animals after insertion of a Hufnagel ball-valve prosthesis (1, 2). It was assumed that direct action of the ball-valve on erythrocytes was responsible for erythrocyte damage and destruction. Hemodynamic disturbance with turbulence of blood flow was subsequently implicated by several investigators as being the
PIROFSKY B. Hemolysis in Valvular Heart Disease. Ann Intern Med. ;65:373–376. doi: 10.7326/0003-4819-65-2-373
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Published: Ann Intern Med. 1966;65(2):373-376.
Cardiology, Valvular Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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