ALLEN B. COHEN, M.D.
Triamterene (2,4,7-triamino-6-phenylpteridine),1 a potassium-retaining diuretic, has been used since 1961 (1). Its principal effect is on the distal tubule where it inhibits sodium reabsorption and potassium secretion (2). It behaves like an aldosterone antagonist but functions in adrenalectomized animals (3) and in patients when aldosterone has been chemically blocked (3, 4).
Triamterene has been used in the treatment of various edematous states, including congestive heart failure, hepatic cirrhosis with ascites, and the nephrotic syndrome. Most studies have been short term and have involved groups of patients who were heterogeneous with respect to age and disease (5-9). Baba, Tudhope, and Wilson
COHEN AB. Hyperkalemic Effects of Triamterene. Ann Intern Med. ;65:521–527. doi: 10.7326/0003-4819-65-3-521
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Published: Ann Intern Med. 1966;65(3):521-527.
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