HAROLD O. CONN, M.D.; RICHARD QUINTILIANI, M.D.
The description of agammaglobulinemia by Bruton (1) in 1952 initiated reports of a variety of hypoagammaglobulinemic syndromes and stimulated an enormous amount of research in infectious disease and immunology. Among the clinical variants of hypogammaglobulinemia reported were sprue-like syndromes, anemias of diverse type, and a high prevalence of thymoma. The present report concerns a patient with adult-onset, "acquired" hypogammaglobulinemia who had severe diarrhea which was controlled by the administration of gamma globulin. In addition, amyloidosis and a thymoma were found at autopsy. The purpose of this paper is to define possible relationships among these abnormalities by reviewing the previously reported
CONN HO, QUINTILIANI R. Severe Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and Thymoma. Ann Intern Med. 1966;65:528–541. doi: 10.7326/0003-4819-65-3-528
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Published: Ann Intern Med. 1966;65(3):528-541.
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