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Increased understanding of the underlying defects in circulatory shock has presented the clinician with new challenges in management of patients. The authors have attempted to delineate the issues and present the rationale for opposing modalities of treatment in terms of the pharmacological principles.
The issue of "vasopressor" or "vasodilator" therapy has been prefaced with a detailed explanation of the concept of alpha- and betareceptors. Effects of vasoactive drugs have been evaluated in terms of their actions on the heart, resistance, and capacitance vessels. Problems relating to acidosis, adrenocortical steroids, and arrhythmias have also been explored, but less extensively. Hypovolemia, although
Shock: Pharmacological Principles in Treatment.. Ann Intern Med. 1966;65:619. doi: 10.7326/0003-4819-65-3-619_1
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Published: Ann Intern Med. 1966;65(3):619.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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