HARRY N. BEATY, M.D.; MARVIN TURCK, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.
The currently recommended treatment for enterococcal endocarditis consists of high doses of aqueous penicillin intravenously, given in combination with intramuscular streptomycin for 6 weeks (1). If antibiotic dosage is regulated to maintain a constant bactericidal activity against the infecting strain in at least a 1:4 dilution of the patient's serum, the bacteriologic cure rate for this infection approaches that achieved for highly penicillin-sensitive Streptococcus viridans endocarditis (1, 2). Although the penicillin-streptomycin regimen is eminently satisfactory from the therapeutic point of view, it involves considerable inconvenience, cost, and the potential risk of ototoxicity. For these reasons, it seems reasonable to seek
BEATY HN, TURCK M, PETERSDORF RG. Ampicillin in the Treatment of Enterococcal Endocarditis. Ann Intern Med. ;65:701–707. doi: 10.7326/0003-4819-65-4-701
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Published: Ann Intern Med. 1966;65(4):701-707.
Cardiology, Endocarditis, Infectious Disease.
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