KUNIO OKUDA, M.D.; HISATOSHI TAKEDATSU, M.D.
To the Editor: We read with great interest the article by Dr. G. J. Ellis and his associates in the March 1966 issue of this journal on a patient with pernicious anemia who developed clinical evidence of combined system disease during the course of adequate parenteral vitamin B12 therapy.
Their patient apparently had recurrent bouts of diarrhea and then developed posterolateral spinal column involvement in spite of B12 administration. The spinal lesion in this case might be entirely unrelated to B12 deficiency and reminds us of a new disease entity that has recently received general attention in Japan. The disease
OKUDA K, TAKEDATSU H. COMBINED SYSTEM DISEASE IN VITAMIN B12-TREATED PERNICIOUS ANEMIA. Ann Intern Med. ;65:865. doi: 10.7326/0003-4819-65-4-865_1
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Published: Ann Intern Med. 1966;65(4):865.
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