PETER H. ABBRECHT, M.D., PH.D.; JAMES A. GREENE JR., M.D.
Considerable information concerning the hormonal control of erythropoiesis can be gained from long-term studies of patients who receive renal transplants. The purpose of our study was to investigate the relationships among serum erythropoietin, erythropoiesis, renal function, and drug therapy in patients undergoing renal transplantation. A preliminary report of this work has appeared elsewhere (1).
Decreased erythropoiesis is a major factor in the anemia of chronic renal failure (2-6). Normally the kidney produces or activates the hormone erythropoietin which regulates the rate of erythropoiesis in response to stimuli such as hypoxia and anemia (7-10). However, there is increasing evidence that in
ABBRECHT PH, GREENE JA. Serum Erythropoietin After Renal Homotransplantation. Ann Intern Med. ;65:908–921. doi: 10.7326/0003-4819-65-5-908
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Published: Ann Intern Med. 1966;65(5):908-921.
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