JAMES C. GUCKIAN, M.D.; JOHN E. PERRY, M.D.
Granulomas in the liver may result from many diseases of man. One of the most perplexing problems in medicine is to arrive at a diagnosis in a patient whose liver biopsy shows noncaseating granulomas in the absence of identifiable organisms. This is not an uncommon problem as reflected by a 3 to 10% prevalence of granulomas in liver biopsies performed at general hospitals (1-4). There are several reviews of hepatic granulomas (4-7), and Table 1 lists the various diseases with which they have been associated.
Although there are many causes for granulomatous hepatitis, it is probable that the pathogenesis is
JAMES C. GUCKIAN, JOHN E. PERRY. Granulomatous Hepatitis: An Analysis of 63 Cases and Review of the Literature. Ann Intern Med. 1966;65:1081–1100. doi: 10.7326/0003-4819-65-5-1081
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Published: Ann Intern Med. 1966;65(5):1081-1100.
Gastroenterology/Hepatology, Liver Disease.
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