DEAN T. MASON, M.D.; KENNETH L. MELMON, M.D.
Although it is now well established that an overproduction of serotonin (5-hydroxytryptamine) consistently attends the carcinoid syndrome, attention has recently been focused on the elaboration of other physiologically active substances in patients with carcinoid tumors. A variety of clinical and pathologic features distinct from those ordinarily associated with the ileal carcinoid tumor have been described, and the importance attributed to serotonin as the sole mediator of carcinoid symptomatology has been challenged (1-5). Thus, the carcinoid tumor may possess multiple endocrine properties capable of producing a spectrum of clinical conditions rather than a single syndrome. Indeed, elevated excretions of urinary histamine,
MASON DT, MELMON KL. New Understanding of the Mechanism of the Carcinoid Flush. Ann Intern Med. 1966;65:1334–1339. doi: 10.7326/0003-4819-65-6-1334
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Published: Ann Intern Med. 1966;65(6):1334-1339.
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