JAIME F. BRAVO, M.D.; JEROME H. HERMAN, M.D.; CHARLEY J. SMYTH, M.D. F.A.C.P.
In recent years evidence has accumulated that immunological phenomena may be involved, at least secondarily, in the pathogenesis of some of the rheumatic diseases. Similar phenomena occur in the recipients of renal homografts as a result of indigenous incompatibility factors existing between the host and recipient tissues. Waller, Irby, Mullinax, and Toone (1) recently reported connective-tissue disorders characterized by periarticular pain, transient synovitis, dermatologic lesions, and peripheral neuritis in 12 of 21 recipients of renal homotransplants. Rheumatoid-factor activity was detected in the sera of 66% of their patients. These findings led to investigations reported here of the mechanisms operative in
BRAVO JF, HERMAN JH, SMYTH CJ. Musculoskeletal Disorders After Renal Homotransplantation: A Clinical and Laboratory Analysis of 60 Cases. Ann Intern Med. ;66:87–104. doi: 10.7326/0003-4819-66-1-87
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Published: Ann Intern Med. 1967;66(1):87-104.
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