R. H. SHEPPARD, M.D., F.R.C.P.(C); H. E. MEEMA, M.D.
In the past, little attention has been paid to the significance of alterations in skin thickness in disease. It has been observed that the skin appears thick in acromegaly and myxedema and thin in Cushing's syndrome and hyperthyroidism. The evaluation of such changes by palpation is understandably inexact. In addition, the impressions gained may be influenced by changes in the skin which are unrelated to its thickness, such as alterations in elastic fibers, differences in the amount of subcutaneous fat, and variations in hydration (edema, dehydration). While the actual in vivo measurement of the combined thickness of skin and subcutaneous
SHEPPARD RH, MEEMA HE. Skin Thickness in Endocrine Disease: A Roentgenographic Study. Ann Intern Med. ;66:531–539. doi: 10.7326/0003-4819-66-3-531
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Published: Ann Intern Med. 1967;66(3):531-539.
Endocrine and Metabolism.
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