RALPH GIANELLY, M.D.; JOHN R. GRIFFIN, M.D.; DONALD C. HARRISON, M.D.
The sympathetic nervous system exerts an important influence on the regulation of heart rate. The ventricular rate may be increased either by stimulating the cardiac sympathetic nerves (1) or by administering catecholamines (2). This excitatory influence on the heart rate is generally considered to be mediated by the beta-adrenergic neuroreceptors of Ahlquist's classification (3). Blockade of the beta-adrenergic system would therefore be expected to alter the heart rate and consequently to have an effect in patients with a variety of cardiac arrhythmias. Although dichloroisoproterenol was the first specific beta blocking drug, it was not widely used because of its sympathomimetic
GIANELLY R, GRIFFIN JR, HARRISON DC. Propranolol in the Treatment and Prevention of Cardiac Arrhythmias. Ann Intern Med. ;66:667–676. doi: 10.7326/0003-4819-66-4-667
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Published: Ann Intern Med. 1967;66(4):667-676.
Cardiology, Rhythm Disorders and Devices.
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