DONALD H. HANSCOM, M.D.; BURTON M. JACOBSON, M.D.; ARMAND LITTMAN, M.D., PH.D., F.A.C.P.
The secretin test has become well established for the diagnosis of pancreatic disease (1), but it may not be helpful when the disease is of limited extent or severity (2). It was hoped that pancreozymin preparations, as a stimulant to enzyme output, would add to the diagnostic value of secretin. This hope has not thus far been fulfilled.
Increasing the dose of pancreozymin progressively improved the differentiation of normal from abnormal responses (3), but the dose-response relationship was linear only when initial doses were excluded; that is, responses to initial doses of pancreozymin were more variable than to subsequent doses.
HANSCOM DH, JACOBSON BM, LITTMAN A. The Output of Protein After Pancreozymin: A Test of Pancreatic Function. Ann Intern Med. ;66:721–726. doi: 10.7326/0003-4819-66-4-721
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Published: Ann Intern Med. 1967;66(4):721-726.
Gastroenterology/Hepatology, Hospital Medicine, Pancreatic Disease.
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