THOMAS W. SHEEHY; RICHARD C. REBA
Infection with Plasmodium falciparum may result in such potentially lethal complications as acute renal failure, blackwater fever, cerebral malaria, and pulmonary involvement. These complications developed in 1.1% of 3,300 cases in Vietnam (Table 1) and in them resulted in a total fatality rate of approximately 0.3%. Two factors correlated well with their development. One was an overwhelming infection; any patient with an intense parasitemia (400,000 parasites/mm3) was in danger of developing a major complication. The other was delay in treatment due either to misdiagnosis, to lack of a positive malaria smear, or to patients' failure to seek medical help.
SHEEHY TW, REBA RC. Complications of Falciparum Malaria and Their Treatment. Ann Intern Med. ;66:807–809. doi: 10.7326/0003-4819-66-4-807
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Published: Ann Intern Med. 1967;66(4):807-809.
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