FRANCIS C. WOOD JR., M.D.; DANIEL PORTE JR., M.D.
In recent months corroborating reports have established two new facts about glucagon:  Glucagon is a potent stimulus to insulin release, and  glucagon, or a compound closely related immunochemically and physiologically, can be isolated from the gastrointestinal tract. These unanticipated discoveries are leading to a reappraisal of the concept that the major role of glucagon is the maintenance of glucose homeostasis by increasing hepatic glucose production during hypoglycemia or starvation.
Early demonstrations of insulin release after glucagon administration were thought to reflect a secondary response to induced hyperglycemia. However, insulin release has been shown in vitro to occur without
WOOD FC, PORTE D. A New Role for Glucagon. Ann Intern Med. ;66:812–813. doi: 10.7326/0003-4819-66-4-812
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Published: Ann Intern Med. 1967;66(4):812-813.
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