ALFONSE T. MASI, M.D., DR.P.H., F.A.C.P.; WILLIAM A. D'ANGELO, M.D.
Little is known about the factors that predispose to systemic sclerosis (diffuse scleroderma) or that influence its usually progressive and fatal outcome. Epidemiologic studies, which relate cases to a defined community population, may reveal clues to personal, socioeconomic, or environmental determinants in this disease of unknown cause. A community-wide survey, furthermore, promises a larger and more representative sample of cases than might be found at a single institution. This improved sample of patients offers a better opportunity to define the characteristics and natural history of the disease.
No previous population study of systemic sclerosis has been reported, and this paper
MASI AT, D'ANGELO WA. Epidemiology of Fatal Systemic Sclerosis (Diffuse Scleroderma): A 15-Year Survey in Baltimore. Ann Intern Med. ;66:870–883. doi: 10.7326/0003-4819-66-5-870
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Published: Ann Intern Med. 1967;66(5):870-883.
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