DAVID E. COMINGS, M.D.; K. B. SKUBI, M.D., F.A.C.P.; J. VAN EYES, PH.D., M.D.; ARNO G. MOTULSKY, M.D., F.A.C.P.
Sclerosing Overgrowths of fibrous tissue have long been known to affect a number of widely separate organ systems. The terms retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's sclerosing thyroiditis, and pseudotumor of the orbit reflect the multiple areas involved. Despite the tendency to treat these entities as independent diseases, an increasing number of patients has been reported with fibrotic involvement of more than one of the above areas. With the exception of the recent evidence that methysergide (Sansert®) may produce retroperitoneal fibrosis, the cause of these diverse disorders has remained unknown. The present report concerns two brothers, offspring of a
DAVID E. COMINGS, K. B. SKUBI, J. VAN EYES, ARNO G. MOTULSKY. Familial Multifocal Fibrosclerosis: Findings Suggesting that Retroperitoneal Fibrosis, Mediastinal Fibrosis, Sclerosing Cholangitis, Riedel's Thyroiditis, and Pseudotumor of the Orbit May Be Different Manifestations of a Single Disease. Ann Intern Med. 1967;66:884–892. doi: 10.7326/0003-4819-66-5-884
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Published: Ann Intern Med. 1967;66(5):884-892.
Biliary Disorders, Endocrine and Metabolism, Gastroenterology/Hepatology, Thyroid Disorders.
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