BARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P.; BETTY JANE S. GERSTLEY, M.D.; DAVID A. HUNGERFORD, PH.D.; W. THOMAS LONDON, M.D.; ALTON I. SUTNICK, M.D., F.A.C.P.
We have previously reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia (1, 2). The "new" isoantigen has been called "Australia antigen" because it was first found in the serum of an Australian aborigine. It appears to be different from the low-density lipoprotein isoantigen system first described in our laboratory (3-5). Hemophilia patients and others who have received multiple transfusions may develop precipitating isoantibodies against Australia antigen. These precipitating isoantibodies react with a protein in the blood of some normal and some
BLUMBERG BS, GERSTLEY BJS, HUNGERFORD DA, LONDON WT, SUTNICK AI. A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and Hepatitis. Ann Intern Med. ;66:924–931. doi: 10.7326/0003-4819-66-5-924
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Published: Ann Intern Med. 1967;66(5):924-931.
Gastroenterology/Hepatology, Hematology/Oncology, Leukemia/Lymphoma, Liver Disease, Neurology.
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