RUSSELL E. RANDALL JR., M.D.
To the Editor: The family with renal tubular acidosis reported in 1961 (1) has now been observed for 6 years.
Two new cases (Members IV-8 and IV-10) have been documented in the fourth generation (Figure 1), further supporting the concept that the disorder is governed by an autosomal dominant gene. Both have hyperchloremic acidosis, a persistently alkaline urine, and minimal nephrocalcinosis. Member IV-8 at 1 month of age was unable to elaborate a urine more acid than pH 6.5 despite a serum bicarbonate of 11 mmoles/liter during ammonium chloride loading. Nephrocalcinosis was detected in this child at age 3 when
RANDALL RE. FAMILIAL RENAL TUBULAR ACIDOSIS REVISITED. Ann Intern Med. ;66:1024–1025. doi: 10.7326/0003-4819-66-5-1024_2
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Published: Ann Intern Med. 1967;66(5):1024-1025.
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