W. D. Hawley, M.D. (Associate); C. Y. Bowers, M.D., F.A.C.P.
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A commercially available nonprotein polysaccharide-nucleic acid complex prepared from Pseudomonas (Piromen®) is used as a standardized stimulus to evaluate the function of the hypothalamus-pituitary-adrenal cortical axis in hospitalized or ambulatory patients. The test is performed as follows: 2.5 ml plasma are obtained from blood collected in a heparinized vacuum tube at 8 AM after an overnight fast; Piromen, 0.1 µg/kg of body weight, is given intravenously; and 2.5 ml of plasma are obtained 2 hr later. Plasma cortisol concentration is determined by a fluorometric procedure. Simplicity and lack of serious side effects recommend the test for a variety of studies.
Hawley WD, Bowers CY. Pseudomonas Polysaccharide (Piromen®) in the Evaluation of the Hypothalamus-Pituitary-Adrenal Cortical Axis.. Ann Intern Med. 1967;66:1028. doi: 10.7326/0003-4819-66-5-1028_1
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Published: Ann Intern Med. 1967;66(5):1028.
Adrenal Disorders, Endocrine and Metabolism, Infectious Disease, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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