Marshall Nirenberg, Ph.D.
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One strand of deoxyribonucleic acid is transcribed into messenger ribonucleic acid (RNA), which then directs the synthesis of protein. The RNA message is read starting from a fixed point, from left to right, three bases at a time without overlapping bases. Two or more structurally related RNA code words have been found for most amino acids. Usually, synonym words contain the same bases in the first and second positions of the triplet and alternate bases in the third position. Probable consequences of a logically degenerate code will be discussed. Some code words play special roles in protein synthesis, such as
Nirenberg M. The American College of Physicians Award Lecture: Genetic Information Processing.. Ann Intern Med. 1967;66:1030. doi: 10.7326/0003-4819-66-5-1030_1
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Published: Ann Intern Med. 1967;66(5):1030.
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