William B. Thorsen Jr., M.D.; Dennis Western, B.A.; Yoshihisha Tonaka, M.D.; John F. Morrissey, M.D., F.A.C.P.
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The effect of pH on the toxicity of acetylsalicylic acid to the gastric mucosa was studied in 20 healthy volunteers. Subjects were studied at weekly intervals, 30 min after ingestion of acetylsalicylic acid tablets (0.6 g) with 100 ml of 1.0 N sodium bicarbonate, pH 8.3, or with 100 ml of 0.1 N hydrochloric acid, pH 1.3. Alkaline and acid solutions ingested with placebo tablets were controls. Ten subjects ingested acetylsalicylic acid (2.4 g) daily for 5 days. A 7-day minimum was allowed between examinations to permit the gastric mucosa to return to normal. Mucosal changes were documented by intragastric
William B. Thorsen, Dennis Western, Yoshihisha Tonaka, John F. Morrissey. The Effects of pH on Gastric Mucosal Toxicity of Acetylsalicylic Acid—A Gastrocamera Study.. Ann Intern Med. 1967;66:1032–1033. doi: 10.7326/0003-4819-66-5-1032_3
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Published: Ann Intern Med. 1967;66(5):1032-1033.
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