William B. Thorsen Jr., M.D.; Dennis Western, B.A.; Yoshihisha Tonaka, M.D.; John F. Morrissey, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
The effect of pH on the toxicity of acetylsalicylic acid to the gastric mucosa was studied in 20 healthy volunteers. Subjects were studied at weekly intervals, 30 min after ingestion of acetylsalicylic acid tablets (0.6 g) with 100 ml of 1.0 N sodium bicarbonate, pH 8.3, or with 100 ml of 0.1 N hydrochloric acid, pH 1.3. Alkaline and acid solutions ingested with placebo tablets were controls. Ten subjects ingested acetylsalicylic acid (2.4 g) daily for 5 days. A 7-day minimum was allowed between examinations to permit the gastric mucosa to return to normal. Mucosal changes were documented by intragastric
Thorsen WB, Western D, Tonaka Y, Morrissey JF. The Effects of pH on Gastric Mucosal Toxicity of Acetylsalicylic Acid—A Gastrocamera Study.. Ann Intern Med. ;66:1032–1033. doi: 10.7326/0003-4819-66-5-1032_3
Download citation file:
Published: Ann Intern Med. 1967;66(5):1032-1033.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use