John W. Adams, M.D.; Clement A. Finch, M.D.
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Red cell overproduction can be visualized best as a disturbance in the self-regulating system that characterizes the control of normal erythropoiesis: the relationship of oxygen delivery to tissue, erythropoietin release, and resultant erythroid marrow activity.
Quantitative measurements of marrow production and oxygen transport are well developed, but only recently have meaningful measurements of erythropoietin, able to detect subnormal as well as normal excretion in human urine, provided an even better understanding of disordered erythropoiesis. Using such methods, it is possible to classify conditions of red cell overproduction into three categories: (1) tissue anoxia, (2) autonomous erythropoietin production, and (3) autonomous
John W. Adams, Clement A. Finch. A Physiological Approach to Polycythemia.. Ann Intern Med. 1967;66:1040. doi: 10.7326/0003-4819-66-5-1040_1
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Published: Ann Intern Med. 1967;66(5):1040.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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