William Dameshek, M.D., F.A.C.P.
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Chronic lymphocytic leukemia (CLL) may be classified as one of the immunoproliferative disorders; these are self-perpetuating growth abnormalities of one of the cells of the immunocyte complex. The normal lymphocyte, which may be termed the "central" immunocyte, transforms or dedifferentiates in response to antigenic materials in vivo and to phytohemagglutinin and specific antigens in vitro. In chronic lymphocytic leukemia, this transformation capacity is either lost or greatly reduced, and in addition, ribonucleic acid and deoxyribonucleic acid production are severely limited. Other indications of abnormality are found by cytochemical studies (periodic acid-Schiff, beta-glucuronidase). It may be said that the lymphocytes of
William Dameshek. Chronic Lymphocytic Leukemia—An Accumulative Disorder of Immunologically Incompetent Lymphocytes.. Ann Intern Med. 1967;66:1040–1041. doi: 10.7326/0003-4819-66-5-1040_3
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Published: Ann Intern Med. 1967;66(5):1040-1041.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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