Bruce L. Evatt, M.D.; Allen M. Mondzac, M.D.; J. Richard Gaintner, M.D.
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Although acute monocytic leukemia is a relatively well-defined clinical entity, the chronic form of monocytic leukemia has been given little attention. Some authors even question its existence. Since 1955 there have been 25 patients at the Johns Hopkins Hospital with a syndrome that is appropriately designated "chronic monocytic leukemia." These cases were mainly characterized by a long preleukemic phase with proliferative dysfunction of various blood elements, even before monocytes were present in sufficient numbers to make the diagnosis. The most common blood abnormality was that of refractory anemia and was present as long as 16 years before the onset of
Evatt BL, Mondzac AM, Gaintner JR. Chronic Monocytic Leukemia: A Clinical Appraisal.. Ann Intern Med. ;66:1041–1042. doi: 10.7326/0003-4819-66-5-1041_3
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Published: Ann Intern Med. 1967;66(5):1041-1042.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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