Virgil F. Fairbanks, M.D., F.A.C.P.
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Previous studies have shown that hemolytic drugs inhibit glucose-6-phosphate dehydrogenase in hemolysates, or oxidize glutathione in hemolysates, or alter the erythrocyte membrane.
Development of a new cytochemical stain, specific for activity of the pentose-phosphate glycolytic pathway, has made it possible to study the effect of hemolytic drugs in individual, intact, metabolically active erythrocytes. These studies have shown that primaquine, sulfonamides, nitrofurantoin, and 1-acetylphenylhydrazine do not inhibit the pentose shunt when incubated in concentration as high as 10-2 M with intact normal human erythrocytes. Of these substances, only 1-acetylphenylhydrazine can be clearly shown to gain access to the interior of the
Fairbanks VF. Studies of Glycolysis in Individual Intact Human Erythrocytes by a New Cytochemical Technique: The Mechanisms of Hemolytic Drug Action.. Ann Intern Med. ;66:1042. doi: 10.7326/0003-4819-66-5-1042_1
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Published: Ann Intern Med. 1967;66(5):1042.
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